Full mouth rehabilitation (FMR) is a comprehensive prosthodontic procedure aimed at the restoration and maintenance of oral function, esthetics, health, and comfort in patients with severely worn dentition, mutilated arches, or generalized oral dysfunction. This review elaborates on the principles, indications, and techniques of FMR with a detailed focus on the Pankey-Mann-Schuyler philosophy and Hobo's Twin-Stage and Twin-Table techniques.