The article presents the results of a clinical study aimed at assessing the effectiveness of a personalized medical rehabilitation program for boys after surgical treatment of urolithiasis (ULD). The study included 62 patients divided into the main and control groups, depending on the use of a comprehensive rehabilitation program, including metabolic correction, physiotherapy, diet therapy and psychoemotional support. Risk stratification, comparative analysis of clinical and laboratory parameters, biochemical markers, ultrasound signs and the frequency of complications within 6 months were carried out. It was found that the introduction of a personalized approach provides a reliable improvement in the functional state of the kidneys, a decrease in the frequency of relapses and urinary tract infections compared to standard tactics. The data obtained confirm the need to introduce personalized rehabilitation into the practice of pediatric urology and nephrology as an effective method of secondary prevention and improving the quality of life of patients.