This article presents the results of a prospective study aimed at developing and implementing a clinical and organizational algorithm for personalized postoperative care for newborns with congenital intestinal obstruction (CIO). The study included 82 patients divided into two groups: one received standard medical care, the other received individualized care, including thermoregulation control, early nutritional support, prevention of complications and comprehensive monitoring of the condition. The results showed that the use of a personalized algorithm contributed to a significant reduction in the time of stabilization of vital functions, a decrease in the incidence of infectious complications and nutritional disorders, a decrease in the duration of hospitalization and artificial ventilation. An increase in the level of overall clinical improvement was also noted. The data obtained confirm the effectiveness of a multidisciplinary and individualized approach to the care of newborns with CIO.