stdClass Object
(
    [id] => 17710
    [paper_index] => 202509-02-024231
    [title] => FORMULATION DEVELOPMENT AND EVALUATION OF FLOATING MICROSPHERE OF CEFUROXIME AXETIL
    [description] => 
    [author] => Roshni Rahangdale, Dr Vijendra Nath Trivedi
    [googlescholar] => 
    [doi] => 
    [year] => 2025
    [month] => September
    [volume] => 10
    [issue] => 9
    [file] => fm/jpanel/upload/2025/October/202509-02-024231.pdf
    [abstract] => This study focuses on the formulation and evaluation of floating microspheres containing Cefuroxime axetil, a broad-spectrum cephalosporin antibiotic, to create a gastroretentive drug delivery system. The goal is to enhance the drug's oral bioavailability by prolonging its residence time in the stomach. Preformulation studies established Cefuroxime axetil's properties: a light-yellow crystalline powder with a bitter taste, soluble in water and 0.1 N HCl, and freely soluble in ethanol, methanol, and chloroform. Its melting point was 132−135∘C, and its λmax was 282.0 nm. The floating microspheres were prepared by the solvent diffusion-evaporation method using HPMC and EC polymers. Formulation F3 was identified as the optimum batch, demonstrating the highest percentage yield (73.32±0.65%), maximum drug entrapment efficiency (75.56±0.23% w/w), and highest buoyancy (76.65±0.52%) with a short floating lag time (32±4 sec). In vitro release studies for the optimized F3 formulation showed sustained drug release, following Zero-order kinetics (R2=0.958). The conclusion is that this delivery system successfully achieves a prolonged gastric residence time and continuous drug release, thereby improving Cefuroxime axetil's absorption and efficacy.
    [keywords] => Cefuroxime axetil; Floating microspheres; Gastroretentive; In vitro release
    [doj] => 2025-10-02
    [hit] => 
    [status] => 
    [award_status] => P
    [orderr] => 42
    [journal_id] => 2
    [googlesearch_link] => 
    [edit_on] => 
    [is_status] => 1
    [journalname] => EPRA International Journal of Research & Development (IJRD)
    [short_code] => IJSR
    [eissn] =>  2455-7838 (Online)
    [pissn] => - -
    [home_page_wrapper] => images/products_image/2-n.png
)
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