The development of controlled oral drug delivery systems is crucial for enhancing patient compliance, improving bioavailability, and extending the duration of drug action. This study focuses on the design, development, and evaluation of floating microspheres of Furosemide using the mixed solvency concept. Furosemide is a high-ceiling diuretic used for oedema, hypertension, and chronic renal insufficiency, acting by inhibiting the Na-K-2Cl symport in the Loop of Henle. Microspheres, defined as solid, approximately spherical particles ranging from 1 to 1000 μm , are a type of drug delivery system that can be classified as microcapsules or micromatrices. The floating drug delivery system aims to prolong gastric residence time and is classified into effervescent and non-effervescent types. Floating microspheres were prepared using various porogens like Hexane and heptane. The physicochemical properties of the drug were confirmed; Furosemide's melting point was found to be 206–208°C , and its solubility was determined in various solvents and across different pH levels, showing a significant increase in solubility with increasing pH. The research involved spectroscopic analysis (FTIR, UV) , particle size determination by optical microscopy, encapsulation efficiency calculation, and in vitro drug release studies. The final drug release profiles suggest the successful formulation of controlled-release floating microspheres, with different batches exhibiting varied release rates over time, indicating the potential for prolonged drug delivery.