Miconazole nitrate-loaded chitosan nanoparticles were prepared by the ionotropic gelation method. The nanoparticles were characterized for percentage yield, drug entrapment efficiency, particle size, and zeta potential. The optimized nanoparticles (Formulation F2) were then incorporated into a Carbopol 934 gel base (Formulations GF1, GF2, GF3). The prepared gels were evaluated for pH, spreadability, viscosity, drug content, extrudability, and in vitro drug release kinetics. The percentage yield of the nanoparticle formulations ranged from 63.12±0.14% to 75.65±0.32%. Drug entrapment efficiency was between 63.32% and 73.23% w/w. The optimized nanoparticle formulation F2 exhibited the maximum percentage yield (75.65±0.32%) and entrapment efficiency (73.23±0.45%), with a mean particle size of 85.6 nm and a zeta potential of −36.2 mV. The prepared gels showed acceptable pH values (6.85-7.02). Viscosity was found to be 4568±13 cps for GF1, 4251±11 cps for GF2, and 3978±14 cps for GF3. In vitro drug release from the optimized gel formulation, GF2, was sustained, reaching 98.85% in 12 hours. The drug release followed the Korsemeyer-Peppas kinetic model (R2=0.986). The Miconazole-loaded chitosan nanoparticles were successfully formulated and incorporated into a gel base, resulting in an optimized topical formulation (GF2) with suitable physicochemical properties for skin application. The formulation achieved sustained and controlled drug release, demonstrating its potential as an effective topical preparation for antifungal effects.