stdClass Object
(
    [id] => 17714
    [paper_index] => 202509-02-024240
    [title] => PREPARATION AND EVALUATION OF POLYHERBAL FORMULATION FOR THE TREATMENT OF DIABETES IN RATS
    [description] => 
    [author] => Monika Shukla, Dr Vijendra Nath Trivedi
    [googlescholar] => 
    [doi] => 
    [year] => 2025
    [month] => September
    [volume] => 10
    [issue] => 9
    [file] => fm/jpanel/upload/2025/October/202509-02-024240.pdf
    [abstract] => Diabetes Mellitus (DM) is a chronic disorder characterized by hyperglycemia, with its worldwide prevalence predicted to rise significantly. This study aimed to formulate and evaluate a polyherbal preparation (PHP) containing extracts of four medicinal plants for anti-diabetic activity and to prepare a Fast-Disintegrating Tablet (FDT) dosage form. Hydroalcoholic extracts were prepared from the bark of Cinnamomum zeylanicum (CZ), seeds of Eugenia jambolana (EJ), the whole plant of Vinca rosea (VR), and leaves of Gymnema sylvestre (GS). The extracts were subjected to pharmacognostic, physicochemical, and preliminary phytochemical screening, which confirmed the presence of various constituents like glycosides and alkaloids in all four extracts. Five polyherbal preparations (PHP 1 to PHP 5) were formulated with varying ratios. Acute toxicity studies demonstrated that all PHP formulations were safe at a dose of 2000 mg/kg. Pharmacological evaluation in Streptozotocin (STZ)-induced diabetic Wistar rats showed that PHP-H (PHP-3 at 400 mg/kg) was the most effective in reducing blood glucose levels over 28 days. The optimized PHP-H was then used to formulate Fast Dissolving Tablets (FDTs) using direct compression, with F-8 emerging as the best FDT formulation based on pre-formulation (good flow properties) and tablet evaluation (disintegration time of 291±3 sec and friability of 0.11±0.01%). Stability studies of F-8 showed the formulation remained stable for six months under accelerated conditions.
    [keywords] => Diabetes Mellitus (DM), Polyherbal formulation (PHP), Cinnamomum zeylanicum, Eugenia jambolana, Vinca rosea, Gymnema sylvestre, Streptozotocin (STZ), Fast Disintegrating Tablets (FDT).
    [doj] => 2025-10-02
    [hit] => 
    [status] => 
    [award_status] => P
    [orderr] => 46
    [journal_id] => 2
    [googlesearch_link] => 
    [edit_on] => 
    [is_status] => 1
    [journalname] => EPRA International Journal of Research & Development (IJRD)
    [short_code] => IJSR
    [eissn] =>  2455-7838 (Online)
    [pissn] => - -
    [home_page_wrapper] => images/products_image/2-n.png
)
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