Bullous pemphigoid is a rare and potentially life-threatening autoimmune disorder, forming blisters characterized by disturbed immune system producing antibodies against the structural components that spread from epidermis to the dermis of skin. This immune response leads to inflammation, resulting in intense itching and the formation of blisters. The condition is particularly uncommon in infants. In Ayurveda, its clinical presentation bears a strong resemblance to a condition known as Visphota. This report discusses a case involving an eight-month-old female infant who presented with multiple ruptured blisters and bullae initially localized to the lower abdomen and thighs, which subsequently spread to the back and limbs over a three-month period. The patient was treated with a combination of orally administered Ayurvedic medicines and topical application of an Ayurvedic lotion. Remarkable improvement was observed, with complete recovery achieved within 65days and no signs of relapse noted thereafter.