This article presents the results of a 2020–2024 study of the reproduction biology and ecology of the Great Grey Shrike (Lanius pallidirostris) on the Ustyurt Plateau in Karakalpakstan. Observations were made of abundance, seasonal dynamics, nests, eggs, and chick development. The Great Grey Shrike (Lanius excubitor homeyeri) winters on the Ustyurt Plateau from October to February, while the Great Grey Shrike arrives in March and departs by the end of September. It nests in saxaul at a height of 70–240 cm. Eggs are laid in batches of 4–7, measuring 24–28 × 18–21 mm. Incubation lasts 13–15 days, and the chicks become flightable at 10–14 days, weighing up to 51 g. Chick development is uneven. The desert shrike feeds on insects and lizards, using the food supply around the nest, which helps control pest populations. These data highlight the importance of species conservation and sustainable habitat management.