Background:-The plant eclipta alba commonly known as ‘Bhringraj’,is used as a hepatoprotective agent. In Ayurveda Bhringraj is considered as a powerful liver tonic.It is a weed which grows in tropical and subtropical regions all over the world. It is widely dispersed throughout India,Brazil,Thiland and China.The plant is known to have some important pharmacological activities such as antimicrobial, analgesics, anti-inflammatory ,anti-viral, hepato-protective, etc • Background:- Piper betel linn is commonly known as Paan leaf or betel leaf is belonging to family piperaceae.It have various pharmacological activities like antioxidant, anti-inflammatory and antimicrobial properties. It commonly used as a hepato-protective tonic for liver. • Objective:-The main objective of the study is to evaluate the hepatoprotective activity of combination dose of Eclipta alba and Piper betel against paracetamol or acetaminophene induced hepatotoxicity in albino wistar rats and comparison of results against standard dose of silymarin that is the khown hepatoprotective agent.