Introduction: Artava Kshaya, a condition characterized by scanty or delayed menstruation, is associated with oligomenorrhea in modern medical practice. The imbalance of Vata and Pitta Doshas, along with blockage of reproductive channels (Shrotorodha), is identified as the primary cause of Artava Kshaya in Ayurveda. This case report explores the efficacy of Panchakarma, a classical Ayurvedic purification therapy, in managing Artava Kshaya, using a combination of therapeutic interventions and herbal medications. Materials and Methods: A 29-year-old female patient with complaints of delayed and scanty menstruation was treated using Panchakarma. The treatment protocol included Snehana with Panchatikta Guggulu Ghrita, Swedana, Virechana with Trivrit Leha. Post-Panchakarma, oral medications such as Ashokarishta, Phala Ghrita, and Shatavari Churna were administered. Menstrual regularity, flow, and hormonal balance were measured as the primary outcomes, with symptomatic relief and improved well-being as secondary measures. Results: Following Panchakarma, the patient’s menstrual cycle normalized to 30 days, significantly improving the volume and duration of menstrual flow. Hormonal levels, including FSH, LH, estrogen, and progesterone, returned to normal ranges, correlating with the restored menstrual pattern. The patient also reported relief from associated symptoms like fatigue, bloating, and premenstrual mood swings. No adverse effects were observed during the treatment period. Discussion: The case demonstrates the effectiveness of Panchakarma in treating Artava Kshaya by addressing Vata-Pitta imbalances and clearing reproductive channels. The integrative approach of using Panchakarma therapies such as Virechan along with medications like Phala Ghrita and Shatavari Churna, proved beneficial in regulating menstruation and improving reproductive health. Conclusion: This case highlights the potential of Panchakarma in the successful management of Artava Kshaya, restoring normal menstrual function and improving overall well-being. Further studies with larger populations are recommended to validate these findings and establish the long-term benefits of Ayurvedic treatment for menstrual disorders.