Approximately 58 million persons worldwide suffer from osteoarthritis (OA), a degenerative inflammatory disease of the joint cartilage. Pain, stiffness, and a decreased range of motion in relation to the arthritic joints are its defining characteristics. Over time, these symptoms may increase the risk of diabetes mellitus, falls, fractures, and overweight/obesity. Despite the fact that the current guidelines for treating osteoarthritis (OA) recommend pharmacological treatment, which includes cyclooxygenase (COX)-2-specific drugs, opioids, and non-steroidal anti-inflammatory drugs (NSAIDs), as the gold standard for this condition, there has been a lot of interest in nutraceutical supplements because they contain a diverse class of molecules that have the potential to improve cartilage formation and reduce inflammation, oxidative stress, pain, and joint stiffness. This review's objective is to outline the possible use of nutraceuticals in OA, emphasizing the molecular mechanisms of action as well as any available efficacy and safety evidence.