Turmeric (Curcuma longa) are known to contain curcumin, a lipophilic polyphenol from the curcuminoid group. Curcumin has been used for generations in traditional medicine, due to antioxidant, anti-inflammatory, hepatoprotective, cardio-protective, antimicrobial, nephroprotective, immunomodulatory, hypoglycemic, anti-rheumatic, anti-cancer, and anti-fibrotic properties. Therefore, this study aimed to determine pharmacological activity potential of curcumin using selected test parameters. The results showed that curcumin had antioxidant and anti-inflammatory effects. These effects contributed to various mechanisms of action in numerous diseases, including cardiovascular, anti-cancer, arthritis, brain injury, Alzheimer's, digestive disorders, anti-aging, and hepatoprotection. Several external factors that influenced test results included curcumin dosage, duration of administration, and pain- or disease-inducing ingredients. In long-term therapy with certain drugs, the administration of curcumin could be considered at the right dose to avoid dangerous side effects.