Herbal medicines play an important role in health services around the globe. About three quarters of the world population relies on plants and plant extracts for health care. A large number of Indian medicinal plants are attributed with various pharmacological activities that are widely incorporated into various formulations of cosmetics as well as other medicines. The study focuses on formulation of a Polyherbal Cream that incorporates the potential benefits of turmeric, aloe vera, hibiscus, and moringa oleifera. These natural ingredients have been widely recognized for their medicinal properties and have been traditionally used in skincare remedies. Furthermore, phytochemical screening was performed to identify and quantify the bioactive compounds present in the polyherbal cream. Screening of phytochemical constituents facilitates the assessment of potential therapeutic properties of the cream and understand the chemical composition responsible for its effectiveness. In the evaluation phase, various parameters were assessed to determine the cream's quality and efficacy. These included appearance, texture analysis, spreadability, homogeneity, viscosity and potential therapeutic benefits such as antioxidant and anti-bacterial properties. Among all the prepared formulations (F1-F5). F5 optimized formulation was found to be good in terms of Antibacterial activity, spreadability, Homogeneity, Irritancy, pH, Washability and Dye-solubility. The presence of bioactive compounds and the synergistic effect of these ingredients contribute to the cream's therapeutic properties, including antioxidant and anti-bacterial effects.