FORMULATION AND EVALUATION OF ANTIFUNGAL AND ANTIBACTERIAL CREAM


Faisal Abdul Vahab Dange, Mr. Sachin S. Dighole, Ms. Seema Rathod, Dr. Sunil S. Jaybhaye
Industrial Pharmacy of Institute of Pharmacy (NKSPTS) , Badnapur, Dbatu University Lonere, Raigad, Maharashtra
Abstract
The goal of the study was to formulate a cream with a composition for treating fungal skin infections and which enhances skin properties. This formulation belongs to a medicinal cream that has two antifungal active components. It reveals a formula for treating fungal skin infections, as well as other components that can help improve skin issues. For skin infections, the topical approach is the best option. Because of the numerous advantages over traditional routes of drug administration, the development of topical drug delivery systems with systemic effects appears to be advantageous for a variety of medications. Garlic oil and clove oil are the active pharmaceutical ingredients (API) used to treat fungal skin infections. It also includes two types of primary and secondary emulsifiers, waxy materials, co-solvents, two preservatives, a buffering agent, a humectants, and water in the cream base. When the active components are combined, they provide a potent antifungal effect. Several experiments were done to assess the physicochemical characteristicsof formulated cream, such as visual inspection, pH measurement, extrudability, expandability, skin irritant test, etc. The cream was further analyzed with the use of nutritional agar for antifungal activity. The medicated cream was good in consistency and color; however the smell of the garlic was quite unpleasant, so the odor of the garlic was masked with peppermint oil, which also acting as an additional antifungal agent, in improved version. Most topical preparations are meant to be applied to the skin and therefore basic knowledge Of skin and its physiological function and biochemistry is very important for designing topical formulations. Sweat and fatty acids secreted from sebum influence the pH of the skin surface. It is advocated that the acidity of the skin helps in limiting or preventing the growth of pathogens and other organisms. One promising avenue is the use of herbal gels, which harness the power of natural compounds derived from plants to combat microbial infections. The aim of the study is to formulate and evaluate antibacterial gel containing Pongamia pinnata.
Keywords: Fungal Skin Infections, Garlic Oil, Clove Oil, Peppermint Oil, Antifungal Cream
Journal Name :
EPRA International Journal of Research & Development (IJRD)

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Published on : 2025-12-08

Vol : 10
Issue : 12
Month : December
Year : 2025
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