Background: Inflammatory arthritis of the knee, including osteoarthritis and rheumatoid arthritis, arises from chronic synovial inflammation driven by cytokines such as IL‑1β, TNF‑α, and IL‑6 (1). Ayurveda offers multiple botanicals with proven anti‑inflammatory, antioxidant, and chondroprotective activities. Objective: To review Ayurvedic drugs used in knee inflammatory arthritis, correlating their mechanisms with modern immunological pathways. Methods: Classical Ayurvedic texts and modern scientific literature indexed in Scopus, PubMed, and Web of Science were reviewed. Data on pharmacology, cytokine modulation, and joint‑protective effects were extracted. Results: Thirty Ayurvedic botanicals demonstrated modulation of inflammatory mediators including NF‑κB, COX‑2, 5‑LOX, TNF‑α, IL‑1β, MMP‑3, and ROS. Many showed chondroprotective effects by inhibiting cartilage degradation enzymes and oxidative stress. Conclusion: Ayurvedic botanicals provide mechanistically supported anti‑inflammatory and chondroprotective effects, suggesting usefulness as integrative therapies for knee inflammatory arthritis.