Gridhrasi, classified as a Śhūla-pradhāna Nānātmaja Vātavyādhi, manifests severe radiating pain originating from the Sphik (hip) and extending through the Kaṭi (low back), Ūru (thigh), Jānu (knee), Jaṅghā (calf) up to the Pāda (foot). Depending on Doṣa involvement, it is present in two major forms—Vātaja and Vāta-Kaphaja. Vātaja Gridhrasi is marked by Stambha (stiffness), Ruk (radiating pain), Toda (pricking pain) and Spandana (tingling sensation), whereas Vāta-Kaphaja includes additional features such as Tandrā (lassitude), Gaurava (heaviness) and Arochaka (loss of appetite). Owing to its symptomatology, Gridhrasi shows close clinical resemblance to sciatica, a condition marked by neuralgic pain or paresthesia along the sciatic nerve distribution. Materials and Methods: A single case study of a 61-year-old male patient presenting with complaints of chronic low back pain and tingling sensations radiating towards the right lower limb for the past three months. The treatment protocol included both Śodhana therapy (primarily Yoga Basti) and local procedures (Kaṭi Basti), along with Śhamana auṣadhis. Observations and Results: Post-treatment evaluation using subjective and objective parameters showed marked improvement, with significant reduction in pain and radiating symptoms. Discussion and Conclusion: The therapeutic approach grounded in Vāta-śhamana and Vāta-kapha-hara principles—integrating Yoga Basti, Kaṭi Basti, and appropriate Śhamana auṣadhis—proved effective in alleviating the clinical manifestations of Gridhrasi. This case highlights the potential of Ayurvedic interventions in the successful management of sciatica-like conditions.