Prozocine is a synthetic opioid analgesic belonging to the phenylpiperidine class, developed for the management of moderate to severe pain. The pharmacological activity of Prozocine is primarily mediated through its interaction with opioid receptors in the central nervous system, particularly the μ-opioid receptors, resulting in effective analgesic and sedative effects. In addition to its analgesic action, Prozocine exhibits antitussive and mild anxiolytic properties. Its mechanism of action involves inhibition of pain signal transmission by altering neuronal excitability and neurotransmitter release. Despite its therapeutic benefits, Prozocine shares adverse effect profiles common to opioid drugs, including respiratory depression, nausea, constipation, tolerance, and dependence with prolonged use. Preclinical and limited clinical studies indicate that Prozocine has a rapid onset and moderate duration of action, making it a potential alternative in pain management. This review aims to summarize the pharmacological activities, mechanism of action, therapeutic applications, and safety profile of Prozocine, highlighting its clinical significance and future research prospects.