Grahani Roga is a frequently encountered gastrointestinal disorder in Ayurveda that arises due to impairment of Agni, leading to defective digestion and absorption. The condition manifests with irregular bowel habits, abdominal discomfort, bloating, and systemic weakness. From the perspective of contemporary medicine, Grahani Roga closely resembles Irritable Bowel Syndrome (IBS), a functional bowel disorder characterized by chronic abdominal pain and altered bowel patterns. Sambukadi Vati, a classical Ayurvedic formulation comprising Sambuka Bhasma, Saindhava Lavana, and Madhu, has traditionally been employed in digestive disorders. The present article aims to analyze the probable mode of action and therapeutic relevance of Sambukadi Vati in the management of Grahani Roga with special reference to IBS.