INTRODUCTION: The term Kleda, an Apya Dravya, refers to the general wetness or moisture component found in all Shārīrika Avayavās. Kleda is in two forms - Prākruta and Vikruta Avasthā and is the reason for sustenance and destruction of Dhātu respectively. This demands a precise grasp on crucial role of Kleda in both wellness and illness. METHODS: 1) From Bṛhattrayi detailed literary study and content review of references related to Kleda was performed. 2) A rigorous analysis of involvement of Kleda in Samprāpti of Vyādhi is being done. RESULTS: Samsarga / Sannipātaja / Avarana are the possible presentations of Kleda Pradhāna Vyadhi. Upon investigation, the principles behind dynamics of Kleda and its Vikruti are to be applied for enhancing accuracy and efficacy in treatment. It is impossible to stop the risks caused by persistent disease if one is unaware of role of Kleda in the manifestation of Roga. DISCUSSION AND CONCLUSION: Water is a major component of our body, accounting for 50–60% of your total weight and is vital for human physiology. Kleda is identified by more than just the obvious water component; perhaps there is more to know about Kleda and its role in the pathophysiology of Kleda Pradhāna Vyadhi, which still needs to be explored. Jātharāgni, Dhātvāgni, Bhūtāgni and Tridoshas have their own specific roles to play in homeostasis of Kleda through numerous metabolic processes. As a result of which Kleda is constantly produced and lost from our body. When optimum excretion of Kleda is violated and stagnation occurs, it manifests Roga. Success in both diagnosed and undiagnosed medical conditions requires a thorough understanding of Kleda in relation to Nidāna, Samprāpti and to aim for Samprāpti Vighatana. Therefore, in order to appropriately handle Kleda Pradhāna Vyadhi, it is necessary to grasp Vikruta Kleda and its Samprāpti. The present paper throws a light to understand above aspects.