Introduction: Guillain–Barré syndrome (GBS) is an acute immune-mediated demyelinating neuropathy with significant morbidity despite standard therapy. In Ayurveda, it can be correlated with Sarvangavata. This case report evaluates the effect of Ayurvedic management in GBS. Methods: A 45-year-old male with motor demyelinating GBS and a Guillain–Barré Disability Scale score of 3 was treated with Ayurvedic external therapies (Agnilepa, Abhyanga, Shashtikashali Pinda Sweda, and Basti) along with internal medications for 15 days. Results: Post-treatment, muscle power and bulk improved, and the disability score reduced from grade 3 to grade 1. The patient regained independent ambulation without support. Discussion: Ayurvedic interventions based on Vatashamana, Amapachana, and Brumhana principles may support neurological recovery and functional improvement in GBS.