Herbal drugs constitute a significant and rapidly expanding segment of the global pharmaceutical and healthcare industry, primarily due to their natural origin, long-standing traditional usage, and increasing public preference for safer and cost-effective therapeutic alternatives. Derived from various parts of medicinal plants such as roots, leaves, bark, flowers, and seeds, herbal medicines have been utilized for centuries in traditional systems including Ayurveda, Unani, and Siddha. In recent years, the growing concern over adverse effects associated with synthetic drugs, along with increased awareness of preventive healthcare, has accelerated the demand for herbal products across both developing and developed countries. Despite their widespread acceptance, herbal drugs present unique challenges in terms of quality, safety, and efficacy. Unlike synthetic pharmaceuticals, which are chemically well-defined and standardized, herbal formulations often exhibit variability due to multiple influencing factors such as geographical source of raw materials, climatic conditions, harvesting time, processing techniques, and storage practices. Additionally, issues such as adulteration, substitution, contamination with heavy metals, pesticides, and microbial load further complicate the assurance of product quality. These factors highlight the critical need for robust quality control systems and scientifically validated evaluation methods in the herbal drug industry. This study focuses on a comprehensive evaluation of herbal drugs with particular emphasis on their quality control, safety assessment, and therapeutic efficacy. It aims to analyze the various parameters and methodologies used to ensure consistency, purity, and reliability of herbal formulations. Special attention is given to the implementation of Good Manufacturing Practices (GMP) and Good Laboratory Practices (GLP), which serve as fundamental frameworks for maintaining quality standards throughout the manufacturing and testing processes. GMP ensures that herbal products are produced under controlled environmental conditions with proper documentation, hygiene, and process validation, while GLP ensures the accuracy, reliability, and reproducibility of laboratory data used in quality evaluation. In conclusion, herbal drugs have immense potential to contribute to modern healthcare; however, their successful integration depends on the establishment of stringent quality control measures, adherence to GMP and GLP standards, and effective regulatory supervision. With continuous scientific research and technological advancements, herbal medicines can be developed into standardized, safe, and efficacious therapeutic agents suitable for global healthcare applications.