Nursing is considered as caring as well as challenging profession as nurses have to cope with many diverse situations from simple to complex work. This increasing competition and work demand put pressure on nurses physically and psychologically along with a high risk for occupational health problem. Low back pain (LBP) is commonest one. Thus, this study aimed to find out status & factors affecting LBP among nurses. Descriptive cross sectional study with verbal informed consent among 300 registered nurses by using simple random sampling was conducted. Semi structured questionnaires with Numeric Rating Scale (NRS) to measure severity of pain and Measure of Job Satisfaction (MJS), a likert scale to measure job satisfaction for psychological factors were used. Chi square test was used to see association. Among 300 nurses, prevalence of LBP was 68%. The mean age was 30.97±10.22 years. Among 240 nurses with LBP, severity was mild (37.3%). Long service duration >16 years (82.6%), prolong standing for 5-6 hours (73.1%), activity to provide nursing care (63.3%), not maintain good posture (58.1%) and prolong working hours of 47-52 hours/week (89.6%) were factors affecting LBP. MJS scale score was 2.96±0.878 which means subjects were neither satisfied nor dissatisfied. Significant association was found between long service duration, prolong working hours, incorrect posture, performing activity of nursing care and prolong standing. It is recommended to take appropriate measures to reduce long working hours, follow correct body mechanics, promote job satisfaction and to maintain standard nurse patient ratio to reduce work load to nurses in hospital settings.