This study attempts to overcome the challenges of postharvest losses of tomato fruits by examining some botanical extracts as alternative means to the use of synthetic chemicals. Step by step procedures were followed during conducting this work. Two locations were chosen, Sokoto and Shuni, and the samples of spoiled tomato fruits were collected randomly, materials that were used for the analysis were sterilized. bacterial pathogens were isolated at Microbiology Laboratory respectively. The pathogens were also identified after isolation. The identified pathogens were, Saccharomyces cerevisiae, Enterobacter aurogene, Citrobacter freudii Providencia spp. Preparation of crude extracts of neem leaves and garlic bulb and determination of the efficacy of these extracts on identified pathogens were conducted. Each identified pathogens were treated with three different concentrations of both neem and garlic extracts, at 100mg/ml, 200mg/ml, and 300mg/ml and streptomycin was used as control. The zones of inhibition were observed after 24 hours in each and recorded in each sample.