In recent years, the secondary metabolites are extensively investigated as a supply of healthful agents. The sample for the study constitutes Sargassum wightii and Padina gymnospora and it was collected from the Mandapam coast, Rameswaram, TamilNadu, India. Sargassum wightii is belonging to the family Sargassum wightii and Padina gymnospora belonging to the family Dictyotaceae are 2 brown seaweeds better-known for varied biological activities like bactericide, antiviral, inhibitor, opposed cancer, medicine, etc. Five totally different extracts of Sargassum wightii and Padina gymnospora were subjected to phytochemical analysis of secondary metabolites of qualitatively phytochemical screening tests of twelve different chemical compounds (alkaloids, terpenoids, steroids, tannins, saponins, flavonoids, phenols, coumarins, proteins, sugars, quinones, and glycosides). Among the solvent extracts of alga Sargassum wightii and Padina gymnospora showed the utmost presence of saponins, carbohydrates, proteins, and quinines in 3 completely different extracts (ethanol, methanol, water) except solvent and chloroform. So the present study on extractive values of methyl alcohol extract and the binary compound extract was most in each the seaweeds, however, were significantly a lot of in P. gymnopora than S. wightii. Considering their therapeutic uses, like alternative healthful plants there’s a requirement to try pharmacognostic studies of those 2 seaweeds.