SYNTHESIS, CHARACTERIZATION AND ENZYME INHIBITORY STUDIES OF 4-THIAZOLIDONE DERIVATIVES
M.Lalitha,M.Srikanth Goud,Y.Ashwini,S.Vijaya,P.Naresh
assistant professor, k.v.k college of pharmacy
Abstract
A series of new 4-thiazolidinone derivatives was synthesized, characterized by spectral techniques, and screened for All the newly synthesized compounds were screened for in vitro α-amylase inhibitory activity at 5, 10, 25, 50, 100, 200, 400, 500µg/ml concentration. Among the synthesized compounds, T1 and T5 showed good percentage of inhibition at all concentration (5 µg/ml-500 µg). The IC50 values for these compounds were found to be 25 µg/ml and 30 µg/ml respectively which are close to IC50 value of acarbose (10 µg/ml). T3 and T4 showed moderate α-amylase inhibitory activity at all concentrations. The IC50 value for these compounds found to be 59 µg/ml and 110 µg/ml respectively. Among the test compounds, compound 2-(4-chlorophenyl)-3-(4, 6- dimethylpyrimidin-2-yl)thiazolidin-4-one (T1) was found to be the most active agent which showed 88.00 µ g/ml α-amylase inhibition in the highest concentration, which have p-chloro phenyl group in the 4-thiazolidinone nucleus.
Keywords: α-amylase, 4-thiazolidinone, IC50
Journal Name :
VIEW PDF
EPRA International Journal of Research & Development (IJRD)
VIEW PDF
Published on : 2021-06-09
Vol | : | 6 |
Issue | : | 6 |
Month | : | June |
Year | : | 2021 |