stdClass Object
(
    [id] => 5143
    [paper_index] => 202106-02-007294
    [title] => SYNTHESIS, CHARACTERIZATION AND ENZYME INHIBITORY STUDIES OF 4-THIAZOLIDONE DERIVATIVES 
    [description] => 
    [author] => M.Lalitha,M.Srikanth Goud,Y.Ashwini,S.Vijaya,P.Naresh
    [googlescholar] => https://scholar.google.co.in/scholar?hl=en&as_sdt=0%2C5&q=SYNTHESIS%2C+CHARACTERIZATION+AND+ENZYME+INHIBITORY+STUDIES+OF+4-THIAZOLIDONE+DERIVATIVES&btnG=
    [doi] => 
    [year] => 2021
    [month] => June
    [volume] => 6
    [issue] => 6
    [file] => 1247am_13.EPRA JOURNALS-7294.pdf
    [abstract] => A series of new 4-thiazolidinone derivatives was synthesized, characterized by spectral techniques, and screened for All the newly synthesized compounds were screened for in vitro  α-amylase  inhibitory activity at 5, 10, 25, 50, 100, 200, 400, 500µg/ml concentration. Among the synthesized compounds, T1 and T5 showed good percentage of  inhibition at all concentration (5 µg/ml-500 µg). The IC50 values for these compounds were found to be 25 µg/ml and 30 µg/ml respectively which are close to IC50 value of acarbose (10 µg/ml). T3 and T4 showed moderate α-amylase inhibitory activity at all concentrations. The IC50 value for these compounds found to be 59 µg/ml and 110 µg/ml respectively. Among the test compounds, compound 2-(4-chlorophenyl)-3-(4, 6- dimethylpyrimidin-2-yl)thiazolidin-4-one (T1) was found to be the most active agent which showed 88.00 µ g/ml α-amylase inhibition in the highest concentration, which have p-chloro phenyl group in the 4-thiazolidinone nucleus.
    [keywords] => α-amylase, 4-thiazolidinone, IC50
    [doj] => 2021-06-09
    [hit] => 2079
    [status] => y
    [award_status] => P
    [orderr] => 13
    [journal_id] => 2
    [googlesearch_link] => 
    [edit_on] => 
    [is_status] => 1
    [journalname] => EPRA International Journal of Research & Development (IJRD)
    [short_code] => IJSR
    [eissn] =>  2455-7838 (Online)
    [pissn] => - -
    [home_page_wrapper] => images/products_image/2-n.png
)
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