The present investigation was undertaken to develop nnaoparticles of a hydrophilic drug pramipexole dihydrochloride and improve the entrapment efficiency of the drug. Nanosuspension of pramipexole dihydrochloride was prepared with PLGA by the process of modified nanoprecipitation technique. The particle size, zeta potential, SEM, TEM and invitro dug release where performed. Nano-formulations are prepared with different concentrations of PLGA . The formulation variables such as polymer concentration were found to possess significant effect on the particle size and entrapment efficiency of drug in nanosuspension. The maximum entrapment efficiency, least particle size and optimal invitro drug release profile were exhibited with 1;2 ratio of drug and PLGA. The least particle size of 145 nm and maximum zeta potential value 34.8 mv were observed with PMPNP2 formulation. The SEM, TEM and invitro dug release of PMPNP2 were performed shows spherical shape with controlled release when compared to other formulations. PMPNP2 can be selected as best among two best formulations. Thus, the biodegradable polymers influences a better delivery in brain for the treatment in Parkinson’s disease.