A study of the water quality condition of many villages in Rajasthan carried out to asses risk to human health. It was found that ground water of many villages of Rajasthan is contaminated with fluoride by naturally fluoride rich rock salt system. Physicochemical analysis has main consideration to assess the quality of water for its best utilization like drinking ,irrigation. The result of this study helps in enhancing awareness of health hazards of contaminated water. Drinking water with excessive concentration of fluoride causes fluorosis which progresses gradually and becomes a crippling malady in the long run. It affects young, old, poor, rich, rural, and urban population. It has attained a very alarming dimension. Rajasthan suffers both the problems of quantity and quality of water. In most part of the state groundwater is either saline or having high nitrates and fluoride content. Obviously, groundwater is the major source of drinking water and over 94% of the drinking water demand is met by groundwater. Excess fluoride concentration in drinking water has deleterious effects on human health. All the districts in Rajasthan are engulfed by the clutches of fluorosis, to a varying degree. There being no perennial surface source for drinking water, the state is dependent chiefly on groundwater and its level is deeper year-by-year due to over exploitation. As the water table is receding more and more water sources are becoming prone to higher fluoride concentration. The pattern and prevalence of fluorosis in human population are determined by a number of epidemiological factors like water chemistry, demographic and nutritional profile of the community and high mean annual temperature of the area. UNICEF has taken definite steps in collaboration with Government and NGOs, to deal with the problem of fluorosis in Rajasthan. Beside, changing dietary habits, harvesting rainwater and promoting defluoridation of drinking water at household level can yield spectacular results in this regard. Different defluoridation techniques are being tried to make drinking water free from fluoride contamination. Awareness camps are being organized all over the state to make the masses aware of ill effects of fluoride problems. The state government has also taken up various programmed action plans such as artificial recharge of groundwater, rejuvenation of traditional baoris-kunds, RWH and judicious use of underground water for drinking and other purposes. Keeping in view the underground realities, this hydrotoxicants in water supplies of different locations and the people suffering from fluorosis and other ailments were identified in specified zonal localities. [1,2]