This study determined the students with health-related problems and physical activity participation. Specifically, the study sought answers to the following questions: What is the status of the common health-related problems of the students; What is the level of physical activity participation; What is the level of performance in physical education in terms of grades; Is there a significant relationship between health-related problems and performance in physical education; and Is there a significant relationship between physical activity participation and performance in physical education? This study utilized a correlation research design to determine students with health-related problems and physical activity participation. The main source of data of the study is the survey questionnaire which was prepared by the researcher and statistical use of simple descriptive statistics such as the frequency counts and percentages to determine the mean level of the status common health-related problems of the students taking Physical Education subject in Cavite State University Main Campus. In order to conduct this study, letters were sent to the University President of the Cavite State University, Hernando D. Robles EdD. and the Vice President for Academic Affairs, to ask for permission and approval to conduct the study. The self-made questionnaire was checked by the thesis adviser. Face validation of the contents of the questionnaire was done by the adviser of the researcher and other persons with specialization in the field. Researchers used purposive sampling in choosing a specific subset of people to be included as the respondents of the study. Each individual was chosen entirely by chance and each member of the population had an equal chance of being included in the sample. Respondents are the students with health-related problems taking-up Physical Education subject with one hundred one (101) respondents. The purpose of the study is to offer literature and findings that may be useful in conducting future studies more particularly to the students with health-related problems and physical activity participation. The methods used was used statistically analyze and interpret the data gathered through the frequency counts and percentage, weighted mean and the Pearson correlation coefficient which is the statistical test in which the test statistic has an R-value under the null hypothesis. It is appropriate method when correlating statistical models that have been to use to a data set, in order to identify the model that best fits the population from which the data were sampled. The implication of this research is to find out the importance of assessing the students with health-related problems and their physical activity participation in every Physical Education subject. The result showed that there is a significant relationship between health-related problems and performance in physical education. Also, there is a significant relationship between physical activity participation and performance. This will lead to a conclusion that the hypotheses were accepted.