Introduction: All the skin diseases in Ayurveda have been classified under the broad heading, “Kushta”. Dadru is one among Kushta. It involves the clinical features like kandu, raga, pidaka, utsannamandala. Dadru kushta mostly simulates with ‘Dermatophytosis’ commonly referred to as ringworm which is highly contagious. In this study an effort has been made to evaluate the Dadrughna karma (Antifungal activity) of the oil prepared from Dadrughna (Cassia alata Linn) leaves. Materials and methods: In the present study, action of Dadrughna (Cassia alata Linn) patra taila on Dadru kushta was evaluated in 32 subjects who were treated with Dadrughna patra taila as an external application twice a day for 30 days and follow up was done on 45th day. Assessment was done for subjective parameter-itching and objective parameters-distribution of lesion, severity of inflammation, extent of lesion. Results: The effect of therapy was assessed before treatment, 15th day, 30th day of treatment and follow up was done on 45th day. The results were statistically analyzed; it showed significant changes in subjective parameter-itching (p<0.001) and Objective parameters- distribution of lesion (p <0.001), severity of inflammation (p<0.001), extent of lesion (p <0.001). Discussion and conclusion: The external application of Dadrughna patra taila applied for 30 days has helped in reduction of itching, distribution of lesion, extent of inflammation and severity of inflammation where the taila was found more effective in reducing itching when compared to other symptoms