The sustained release drug delivery is the drug delivery system that achieves the release of drug in the proper amount at regular time interval over an extended period of time and is time independent. The aim of present work was to formulate and evaluate sustained release tablets of Clozapine using natural gums in order to reduce the various side effects associated with Clozapine as well as to overcome the manufacturing difficulties. For formulating sustained release drug delivery system, natural hydrophilic polymers are used. Natural binders provides the tablet formulations with good hardness and friability. These binders prolongs the dissolution rate of some slightly soluble drugs and can be chosen as good candidate for sustained release. Tablets were prepared by direct compression method using different drug-polymer concentration. FT-IR study revealed that there was no chemical interaction between the drug and polymers used. Pre- compression and post-compression parameters complied with Pharmacopoeial limit for the tablets. Four different gums (Cassia roxburghii, Tamarindus indica , Azadirachta indica and Manihot esculenta) were used in 3 different concentrations (35%, 50%, 75%) and was compared with the standard rate retardant polymer HPMC. The in vitro release study was performed and the results indicated that the formulation F12 (Neem gum 75%) was found to be the optimized formulation which can extend the release up to a period of 24 hours. The kinetic release data showed that the optimized formulation followed zero order kinetics. From the stability studies it was clear that the formulation was stable after 3 months at accelerated condition of 400C±20C/75% RH±5% in a stability chamber