The majority of drugs used to treat various ailments are taken orally and delivered via a traditional delivery. Because of its weak water solubility, chemical stability, and pre-systemic metabolism, oral administration has a low bioavailability. In terms of solubility and bioavailability, poorly water-soluble drugs pose a challenge to formulation experts. One of the new technologies meant to solve such issues is lipid-based drug delivery systems (LBDDS). Higher solubilization and absorption can be achieved by encapsulating or solubilizing the medicine in lipid excipients, resulting in increased bioavailability. We attempt to explore the different innovative delivery strategies created for the increase of oral bioavailability of poorly water-soluble medicines in this review, as well as the significance of solid lipid nanoparticles in the pharmacokinetics of poorly soluble antihypertensive drugs. Solid lipid nanoparticles may provide new possibilities in the treatment of hypertension with enhanced oral delivery if properly investigated.