Poorly water-soluble drugs remain a challenging, yet significant, class of pharmaceutical substances used to treat a variety of disorders. NSAIDs (nonsteroidal anti-inflammatory drugs) are a class of pharmaceuticals used to treat pain, fever, and other inflammatory conditions. This exercise covers the indications, mechanism of action, administration, side effects, contraindications, monitoring, and key considerations for providers when it comes to NSAIDs. While non-steroidal anti-inflammatory drugs are typically safe, there are certain major side effects that can occur when they are used systemically or orally. The main goal of this paper is to explain the concept of Oral drug delivery, poorly water-soluble drugs and structure of NSAIDs. Because so many patients take nonsteroidal anti-inflammatory drugs, reducing or eliminating these adverse effects, such as by local drug delivery, could have a significant impact on patient quality of life. The next steps and unmet needs are offered as a roadmap for future studies in the field to examine in order to enable progress in NSAID design and development.