The article describes the development of biological and ecological features and harmfulness of melon fly on crops of melons in conditions of Karakalpakstan. It is studied the efficiency of the deep autumn plowing of soil against overwintering pests, special traps to kill the larvae and pupae, chemical treatments against the imaginal phase melon fly on crops of melon. The impact on the conservation of wild melon pest overwintered individuals. Recommended optimal protective measures in extreme conditions of Karakalpakstan.