A Quasi-experimental study to “A Study to Assess and Evaluate the Effectiveness of Structured Teaching Programme on Self Care of Arteriovenous Fistula in Terms of Knowledge and Practice Among Patients with End Stage Renal Disease at Selected Hospital New Delhi” was conducted by Mr. Umesh Kumar Bharati in partial fulfilment of the requirement of the award of a degree Master of Science in Nursing at the Nightingale Institute of Nursing, Noida, Uttar-Pradesh Objectives of the study were, (i) To assess and evaluate the knowledge regarding the self care of Arteriovenous fistula among ESRD patients before and after the Structured Teaching Programme, (ii) To assess and evaluate the practice regarding the self care of Arteriovenous fistula among ESRD patients before and after Structured Teaching Programme, (iii) To find out the relationship between post test knowledge score and post test practice score among ESRD patients, (iv)To find out the association between the post test knowledge score and selected demographic variables, (v) To find out the association between post test practice score and selected demographic variables The conceptual framework was based on Orem’s Self Care Deficit Theory, which focuses on self care of Arteriovenous fistula among end stage renal disease. Essential elements of Orem’s Self Care Deficit Theory are person, goal of nursing, health, environment and nursing activities. In order to maintain homeostasis or integrity, people must respond or adapt to any changes that occur either from internal or external stimuli. Accordingly the study was organized around this conceptual framework. The study made use of quasi experimental one group pre test post-test research design. The study population consisted of ESRD patients who having surgical created AV Fistula who were undergoing Hemodialysis of BLK Super Specialty Hospital, Rajendra place, New Delhi. Total 40 samples were taken with purposive sampling technique. The tool was developed on the basis of “structure knowledge and practice questionnaire”. Steps involved in development of tool were: preparation of the first draft, content validity of tool, reliability of tool, preparation of final draft. Reliability of modified objective of self care was done on 40 AV Fistula patients at BLK Super Specialty hospital. The data was collected from 12th February 2016 to 29th February 2016; after obtaining administrative approval of BLK Super Specialty Hospital New Delhi. The Data was collected through structured knowledge questionnaire. The data gathered was analyzed using evaluative and inferential statistics. The level of significance set for testing the hypothesis was 0.05, using t-test and Kappa test. Major findings of the study were: Analysis shows The pre test mean score and post test mean score was (8.35) and (15.65) respectively.The calculated ‘t’ value was (31.019) is higher than the table value (3.566) at 0.05 level significance at the degree of freedom(39),The pre test mean score and post test mean score was (6.27) and (11.72) respectively. The calculated‘t’ value was (29.879) is higher than the table value (1.684) at 0.05 level significance at the degree of freedom (39) Correlation (‘r’ value) of knowledge and practice of post test was (0.560) The P-Value is 0.000167. The result is significant at p < 0.05. The sample with the number of days that the patient is receiving hemodialysis in a week as shown by the obtained chi value of 9.14 which was greater than the table value of chi square ( 7.815) at Degree of freedom (3) at 0.05 level of significance. The sample with the family income of the patient as shown by the obtained chi value of (11.84) which was greater than the table value of chi square (7.815) at df 3 at 0.05 level of significance.