Introduction In late December 2019, Chinese health authorities reported an outbreak of pneumonia of unknown origin in Wuhan, Hubei Province. A few days later, the genome of a novel coronavirus was released and made publicly available to the scientific community. This novel coronavirus was provisionally named 2019-nCoV, now SARS-CoV-2 according to the Coronavirus Study Group of the International Committee on Taxonomy of Viruses. SARS-CoV-2 belongs to the Coronaviridae family, Beta coronavirus genus, subgenus Sarbecovirus. Since its discovery, the virus has spread globally, causing thousands of deaths and having an enormous impact on our health systems and economies. Aim effectiveness of STP of knowledge regarding prevention of COVID-19 First year B.Sc. Nursing student in Cherraan’s college of nursing at Coimbatore. Methods The study was conducted through a quantitative research approach. The design of the study used in the research was quasi experimental one group pre-test and post-test research design. The duration of the study was two weeks, non-probability convenience sampling was used and sample size was 50 students. Sample The study population was First year B.Sc. nursing students, who are studying in Cherraan’s college of nursing at Coimbatore. Pre-test was conducted with a structured questionnaire, after pre-test STP was administered through PPT for 30 minutes. After the 7th day the post test was conducted with the same questionnaire for the same First year B.Sc. Nursing student. Result The pre-test mean level of knowledge score was 12.88 with SD of 1.41. After the intervention, the post-test mean level of knowledge score was 13.9 with SD of 0.94. The mean difference between the pre-test and post-test was -1.02. Paired ‘t’ test was employed and the calculated ‘t’ was 1.01 which indicates the significant difference between pre-test and post-test level of knowledge score at 0.05 levels. Hence, this finding shows that the STP has a significant effect in increasing the level of knowledge among the First year B.Sc. nursing student regarding prevention ofCOVID-19. Discussion Hypotheses was not proved. The chi-square test shows that there is statistically significant at P<0.05 the level of significance and there was significant no association between the pre-test level of knowledge with selected demographic variables among First year B.Sc. nursing students.