INTRODUCTION: Haemodialysis is a method for removing waste products such as potassium and urea, as well as free water from the blood when the kidneys are in renal failure. Haemodialysis is one of three renal replacement therapies1. Accuracy of figures on RRT prevalence may vary, as few countries have comprehensive dialysis and transplant registries, hence underreporting may be an issue. It is clear, however, that large numbers of people in low- and middle-income countries LMIC die from kidney failure without receiving any treatment. AIM OF THE STUDY: Assess the knowledge regarding risk of complication and their prevention among patients undergoing haemodialysis at tertiary care hospital. MATERIAL AND METHOD: A descriptive study was carried out on 60 patients undergoing hemodialysis at tertiary care hospital Jodhpur. Samples were selected by using Non Probability Purposive Sampling Technique. Data was collected using structured knowledge questionnaire and analyzed by using descriptive and inferential statistics. RESULT: The findings of the study reveals that (53.33%) of patients undergoing haemodialysis had average level of knowledge, the remaining (33.33%) had poor level of knowledge, (13.33%) had good level of knowledge regarding risk of complication and their prevention among patients undergoing haemodialysis. However there was no significant association found between knowledge and selected demographic variables except qualification, types of residence. CONCLUSION: It can be reiterated that patient have average knowledge regarding risk of complication and their prevention as per current research recommendations. They require Regular education program for patients in frequent intervals should be carried out regarding risk of complication and their prevention.