BACKGROUND Malocclusion has been proven to impact periodontal health, increase the prevalence of dental caries, and induce temporo-mandibular joint disorders. Malocclusion is expected to influence a person psychosocially which can be evaluated using one of the questionnaire PIDAQ psychosocial impact of dental esthetic questionnaire. Since, then a number of cross sectional studies have been conducted by evaluating the psychosocial impact of malocclusion an esthetic defect using PIDAQ. A comprehensive examination of more recent knowledge appears justified, as it is necessary to update current understanding on the PIDAQ instrument, giving a solid evidence base for clinical practitioners to rely on it. As a result, the goal of this study was to conduct a systematic evaluation of cross-sectional studies seeking evidence on the psychosocial impact of malocclusion using PIDAQ among 12 to 22 yrs old adolescents. MATERIALS AND METHODS :Seven databases (PuBMed, Cochrane Library, CINAHL, OVID MEDLINE, EMBASE, Grey Literature, Wiley Online Library) were searched using specified indexing terms. PIO and PRISMA (Preferred reporting items for systematic review and metaanalysis) were used. MeSH terms used were were ‘psychosocial impact’AND ‘malocclusion’ AND ‘PIDAQ’ OR ‘psychosocial impact of dental esthetic questionnaire’ AND ‘dental esthetic defect’. RESULTS: Six cross-sectional studies were included in this systematic review for the quality assessment of psychosocial impact of malocclusion a dental esthetic defect using PIDAQ psychosocial impact of dental esthetic questionnaire among 12 to 22 yrs old adolescents. All six studies reported that there is a statistically significant (p<0.001)association between malocclusion and psychosocial impact. CONCLUSION This systematic review concludes that the dental esthetic defect malocclusion has positive effects on psychosocial impact using PIDAQ psychosocial impact of dental esthetic questionnaire with strong scientific evidence.