stdClass Object
(
    [id] => 7585
    [paper_index] => 202209-02-011260
    [title] => A RAPID NOVEL ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF GRAZOPREVIR AND ELBASVIR BY USING RP-HPLC
    [description] => 
    [author] => Vankudoth Kavitha, Usha Kondla, P.V Pavan Kumar,  Gopi Swapna
    [googlescholar] => https://scholar.google.co.in/scholar?q=eprajournals.com&hl=en&scisbd=2&as_sdt=0,5
    [doi] => 
    [year] => 2022
    [month] => September
    [volume] => 7
    [issue] => 9
    [file] => 323pm_18.EPRA JOURNALS 11260.pdf
    [abstract] => The current investigation described a sensitive, selective, precise and accurate RP-HPLC method with photodiode array detector for the simultaneous estimation of antiviral drugs, grazoprevir and elbasvir. The separation and analysis were done on Sunsil C18 analytical column (250 mm x 4.6 mm, 5 μ particle size). 0.1M NaH2PO4: methanol [60:40 v/v] in isocratic elution mode was used as mobile phase. The pH of the mobile was adjusted to 4.0 with orthophosphoric acid. The elution of grazoprevir and elbasvir was accomplished with a flow rate of 1.2 ml/min. Detection was performed with photodiode array detector set at a wavelength of 260 nm. The detector response was linear in the concentration of 25-75 μg/ml for elbasvir and 50-150 μg/ml for grazoprevir. The limit of detection and limit of quantitation values were found to be 0.137 μg/ml and 0. 574 μg/ml for elbasvir and 0.290 μg/ml and 0.968 μg/ml for grazoprevir, respectively. The method was validated following international conference on harmonization guidelines. The percentage recovery for grazoprevir and elbasvir were found to be in the range of 100.08%-100.45% and 99.60%-100.06%, respectively. The %RSD values are 0.130% and 0.161% for grazoprevir and elbasvir, respectively. The results of validation parameters were found in the acceptance range. The present investigation concluded that the RP-HPLC method with photodiode array detector method was selective for simultaneous estimation of elbasvir and grazoprevir in combined dosage form.
    [keywords] => Elbasvir , Grazoprevir ,  Method  Development,RP-HPLC
    [doj] => 2022-09-24
    [hit] => 1689
    [status] => y
    [award_status] => P
    [orderr] => 18
    [journal_id] => 2
    [googlesearch_link] => https://www.google.com/search?q=A+RAPID+NOVEL+ANALYTICAL+METHOD+FOR+SIMULTANEOUS+ESTIMATION+OF+GRAZOPREVIR+AND+ELBASVIR+BY+USING+RP-HPLC+Vankudoth+Kavitha%2C+Usha+Kondla%2C+P.V+Pavan+Kumar%2C+Gopi+Swapna&rlz=1C1CHBD_enIN959IN959&sourceid=chrome&ie=UTF-8
    [edit_on] => 
    [is_status] => 1
    [journalname] => EPRA International Journal of Research & Development (IJRD)
    [short_code] => IJSR
    [eissn] =>  2455-7838 (Online)
    [pissn] => - -
    [home_page_wrapper] => images/products_image/2-n.png
)
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