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Impact Factor SJIF 2021(IJMR 8.047 & IJRD 8.013) Received,  DOI available on request to article , Indexed in Crossref Check ,ISI  Check. -Review Status: 2 Days, Online Publication: 1 Day, E-Certificate: Immediately-Submission Open for OCTOBER 2021 . Submit    
Vol : 7 , Issue : 5 , Month : May , Year : 2021
Journal Name : EPRA International Journal of Multidisciplinary Research (IJMR)
Title : DESIGN AND CHARACTERIZATION OF ERLOTINIB NANOPARTICLES
DOI :
Author names : Shirtha Mupkalkar, Naveena Kommineni, Pingali Srinivasa rao, Vijayabhaskar Kanakam
Abstract : The aim of this study was to formulate and evaluate nine formulations of ERLOTINIB loaded PLGA nanoparticles homogenization followed by solvent evaporation technique by use of biodegradable and biocompatible polymer i.e. PLGA. The effect of different concentrations of polymer and stabilizer (PVA) on particle size, zeta potential, %EE and drug release was studied. PLGA was used in different concentration of 120 mg, 150 mg, and 200 mg. Preformulation studies of FTIR and DSC was done to determine possible interaction between the drug and excipients. A5 showed 75.14% of release after 72 h and followed the fickian diffusion pattern of kinetic. SEM image showed the spherical morphology of nanoparticles.
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