Objective: This study examines the effect of flexible work arrangements on employee productivity in the tech start-up sector in Buea, Cameroon, a context characterised by infrastructural challenges and socio-political crisis. Methodology: A quantitative cross-sectional survey design was employed, collecting primary data from 60 employees working in technology start-ups operating within Buea municipality. Ordinary least squares regression with robust standard errors was used to analyse the relationships between flexible work arrangements (schedule flexibility, location flexibility, autonomy) and employee productivity, controlling for age, gender, education, tenure, and job role. Findings: The regression model explained 67.2% of variance in employee productivity (R² = 0.672, F(8,51) = 28.431, p < 0.001). Schedule flexibility showed a significant positive effect (β = 0.412, p < 0.01), and autonomy demonstrated a significant positive effect (β = 0.348, p < 0.05). Location flexibility showed no significant effect (β = 0.087, p > 0.05). Among control variables, tenure (β = 0.215, p < 0.05) and job role (β = 0.189, p < 0.1) showed positive effects. Recommendations: Tech start-ups in Buea should prioritise schedule flexibility and employee autonomy over location flexibility when designing flexible work policies. Given the context of infrastructure unreliability and security concerns, time-based flexibility proves more valuable than location-based flexibility. Organisations should invest in management training to support flexible work implementation and should recognise that flexible arrangements benefit more experienced employees and technical roles disproportionately. Conclusion: Flexible work arrangements enhance employee productivity in Buea's tech start-up sector, but not all flexibility dimensions are equally effective. Schedule flexibility and autonomy drive productivity gains, while location flexibility offers no additional benefit in a context where remote work is constrained by infrastructure limitations and security concerns.