As the assessment of the association between the Ala222Val polymorphism in the MTHFR gene in the study groups shows, the calculated relative risk of developing MI in patients with a history of COVID-19 increased when the Ala/Val , Val/Val genotypes and the Val allele were detected, and the risk of developing MI in patients without COVID -19 in history increased when an unfavorable Val allele and an unfavorable Ala/Val genotype were detected.