Polycystic ovarian syndrome (PCOS) is an endocrine disorder, which constitutes the most prevalent cause of infertility in women, with increasing incidence day by day affecting one in seven women. It affects the ovaries due to imbalance of reproductive hormones causing ovarian cysts, causing problems like infertility, insulin resistance, and type 2 diabetes. Objective of the study is to understand PCOS through Ayurvedic Samhithas and its clinical management. This paper gives an idea for Ayurvedic approach towards PCOS and its suitable Panchakarma treatment according to different presentation and duration. This paper deals with line of treatment that includes medohara, grantihara chikitsa, since it involves cyst formation and also vatanulomana for proper apana vayu regulation and in correcting menstrual irregularity. And in chronic conditions more than some years urdhwa, adhoghata shodhana, yoni prakshalana, garbhasaya shodhana followed by shamana chiktsa yields a good result.