This study was conducted to determine the effectiveness of the Digital Technology Enhanced Learning Approaches (TELA) Toolkit in teaching Science six during the school year 2020-2021. The study included 10 Grade VI pupils. There were two instruments developed namely the pretest and posttest and the Digital TELA toolkit. Specifically, a pre-experimental design was used to determine the effect of the instructional materials. The study revealed that there was a significant difference between the pretest and posttest of Grade VI pupils. The posttest score of Grade VI pupils in Science was higher than the pretest score. It was concluded that there was a significant difference between the pretest and posttest of Grade VI pupils. This implies that the use of the Digital Technology Enhanced Learning Approaches (TELA) Toolkit was effective in teaching Science in Grade VI pupils. Teachers are encouraged to employ TELA materials as an approach to teaching science. In addition, the Digital Technology Enhanced Learning Approaches (TELA) Toolkit as a tool for instruction should be used for meaningful learning experiences. The researcher highly recommended that it should be used in delivering the lessons, especially during virtual classroom interactions.