Otomycosis is a common clinical condition encountered in a general ENT clinic setting and is typically described as a fungal infection of the ear canal in laymans language. The disease is a challenging and frustrating entity for both patients and the treating doctor due to its complications involving the middle ear and typically requires long-term treatment and follow-up. Ayurveda the ancient science of life states that the Prasannata of Indriya [1] is one of the aspects to state that the individual is healthy and that shows the importance of sense organs to lead a pleasureful life. One of the motives of Ayurveda is getting rid of the disease in diseased [2], one can find descriptions regarding several diseased conditions and guidelines for managing the same. Kaphaja Karna Shoola is a disease condition described under Karna Rogas in classics which finds similarities with Otomycosis clinical presentation. In this article, an attempt is made to discuss a case of Kaphaja Karna Soola.