This study aims to investigate how entrepreneurial orientation and religiosity influence the resilience of MSMEs. This study is both quantitative and descriptive. This research makes use of a survey methodology. Utilizing a questionnaire, data were collected. This study focuses on micro, small, and medium-sized enterprise (MSMEs) actors in the Banyumas and Purbalingga Regencies. This sample was determined using a non-probability sampling strategy, particularly the purposive sampling technique. The findings revealed that entrepreneurial orientation and religiosity have a positive effect on the resilience of MSMEs.