Berberis aristata, commonly known as Daruharidra, is a renowned plant that has been utilized in various medicinal systems such as Ayurveda, Homeopathy, Unani, Chinese, and Allopathic for an extensive period. This versatile medicinal plant is employed either independently or in conjunction with other medicinal herbs to address a diverse range of ailments, including jaundice, leprosy, fever, rheumatism, and more. Belonging to the family Berberidaceae, it is characterized by its spinous, hard, and yellowish herbaceous nature. The plants distribution spans sub-Himalayan regions, Sri Lanka, Bhutan, and the hilly areas of Nepal. Its historical significance as an herbal remedy extends over 2500 years, and it has played a crucial role in traditional medicine. One of its notable formulations, Rasont acts as both a tonic and blood purifier, additionally used in the treatment of ulcers and ophthalmic diseases. Numerous reported clinical and experimental studies highlight the plants diverse pharmacological properties, including antimicrobial, anti-inflammatory, analgesic, antipyretic, hepatoprotective, immunomodulatory, and cardiotonic activities. The wealth of therapeutic attributes associated with Berberis aristata underscores its importance in the realm of natural medicine.