Dermatologic manifestations of renal disease are common findings in patients with end-stage renal disease. This quantitative experimental study investigated the effectiveness of topical application of Avena Sativa on uremic xerosis, hyperpigmentation and pruritus among patients with chronic kidney disease. Background: The effects of chronic kidney disease are complex and may lead to dysfunction of multiple organs, including the skin, most patients presenting with at least one dermatologic alteration. Uremic xerosis, hyperpigmentation and pruritus were having a considerable negative impact on a patients quality of life. Aims: The objectives of the study were evaluating the effectiveness of topical application of Avena Sativa on uremic xerosis, hyperpigmentation and pruritus among patients with chronic kidney disease. Methods: A quasi experimental pre-test-post test control group design was used for the study. The data collected from 60 Chronic kidney disease patients , 30 each in control and experimental group, were selected using non probability purposive sampling technique.On the first day of observation, pre-test was performed. After 24 hours of allergic test, non allergic subjects were selected for the intervention. Post-test was performed on the eighth day of intervention. Results: Avena Sativa had significant effect in reducing uremic xerosis (U=164, p<0.001) hyperpigmentation (U=246, p<0.01) and pruritus (U=202, p<0.01).There was significant association between uremic xerosis and duration of CKD (p<0.01) and positive correlation between uremic xerosis and pruritus (ρ is 0.56 at 0.01 level) Limitations and implications : Randomization was not done and had limited time for the study. A long term study can be conducted to determine the long term effect of topical application of Avena Sativa among patients with chronic kidney disease. Conclusion:Topical application of Avena Sativa was effective in reducing uremic xerosis, hyperpigmentation and pruritus among patients with chronic kidney disease.