This comparative study aims to assess the effectiveness of Sumag dressing and cold compress in reducing intravenous infiltration among patients admitted to the medical and surgical wards of Netaji Subhash Chandra Bose Medical College, Jabalpur. Thrombophlebitis, characterized by inflammation and clot formation in veins, poses a risk during intravenous therapy. Peripheral intravenous devices (PIV) are commonly used in hospitalized patients, yet complications like hematoma, phlebitis, and infections may arise. The study addresses the need to explore interventions for reducing intravenous infiltration, a common issue in medical therapy. Objectives of the study include assessing the extent of intravenous infiltration using the Infusion Nurses Society Infiltration Scale, administering Sumag dressing to one group, applying cold compress to another, and comparing their effectiveness. Additionally, the study aims to examine the association between intravenous infiltration scores and selected socio-demographic variables. Assumptions consider patients on intravenous therapy at risk for infiltration, with the hypothesis predicting a significant difference in the effectiveness of Sumag dressing and cold compress. Furthermore, the study anticipates a significant association between intravenous infiltration and socio-demographic variables. The findings may contribute valuable insights to enhance the management of intravenous therapy complications, ultimately improving patient outcomes.